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CyFlow™ CD2 Purified

CyFlow™ CD2 Purified
Alternative Name: LFA-2
Antibody: Yes
Antigen: CD2
Application: Flow cytometry, Functional assays
Clonality: monoclonal
Clone: TS1/8
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AM526969

For Research Use Only

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Description
HLDA Workshop HLDA V—WS Code S025 Concentration Unit mg/mL Concentration 1... more
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CyFlow™ CD2 Purified
HLDA WorkshopHLDA V—WS Code S025
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenCytotoxic T lymphocytes
Background InformationCD2 (LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA: Three distinct antigens associated with human T‑lymphocyte‑mediated cytolysis: LFA‑1, LFA‑2, and LFA‑3. Proc Natl Acad Sci USA. 1982 Dec; 79(23):7489‑93. < PMID: 6984191 > | Vollger LW, Tuck DT, Springer TA, Haynes BF, Singer KH: Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD‑2 and LFA‑3 antigens. J Immunol. 1987 Jan 15; 138(2):358‑63. < PMID: 3098838 > | Doussis IA, Gatter KC, Mason DY: CD68 reactivity of non‑macrophage derived tumours in cytological specimens. J Clin Pathol. 1993 Apr; 46(4):334‑6. < PMID: 7684403 > | Zhang B, Dai M, Li QJ, Zhuang Y: Tracking proliferative history in lymphocyte development with cre‑mediated sister chromatid recombination. PLoS Genet. 2013 Oct; 9(10):e1003887. < PMID: 24204301 >

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