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CyFlow™ CD1a FITC

CyFlow™ CD1a FITC
Alternative Name: CD1, HTA1, R4
Antibody: Yes
Antigen: CD1a
Application: Flow cytometry
Clonality: monoclonal
Clone: SK9
Emission Maximum: 518 nm
Excitation Maximum: 490 to 495 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: FITC
Isotype: IgG2b
Laser: Blue
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CW604703

For Research Use Only

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Description
HLDA Workshop HLDA II Quantity 100 tests Volume 0.4 mL Immunogen Human... more
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CyFlow™ CD1a FITC

HLDA WorkshopHLDA II
Quantity100 tests
Volume0.4 mL
ImmunogenHuman thymocytes
Background InformationCD1a, together with CD1b and CD1c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Wood GS, Burns BF, Dorfman RF, Warnke RA: The immunohistology of non‑T cells in the acquired immunodeficiency syndrome. Am J Pathol. 1985 Sep; 120(3):371‑9. < PMID: 3898858 > | Zimmer MI, Larregina AT, Castillo CM, Capuano S 3rd, Falo LD Jr, Murphey-Corb M, Reinhart TA, Barratt-Boyes SM: Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood. 2002 Apr 15; 99(8):2859‑68. < PMID: 11929776 > | Tenca C, Merlo A, Zarcone D, Saverino D, Bruno S, De Santanna A, Ramarli D, Fabbi M, Pesce C, Deaglio S, Ciccone E, Malavasi F, Grossi CE: Death of T cell precursors in the human thymus: a role for CD38. Int Immunol. 2003 Sep; 15(9):1105‑16. < PMID: 12917263 > | Brown KN, Trichel A, Barratt-Boyes SM: Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J Immunol. 2007 Jun 1; 178(11):6958‑67. < PMID: 17513745 > | Awasthi S, Wolf R, White G: Ontogeny and phagocytic function of baboon lung dendritic cells. Immunol Cell Biol. 2009 Jul; 87(5):419‑27. < PMID: 19223853 > | Kader M, Smith AP, Guiducci C, Wonderlich ER, Normolle D, Watkins SC, Barrat FJ, Barratt-Boyes SM: Blocking TLR7‑ and TLR9‑mediated IFN‑α: production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS Pathog. 2013; 9(7):e1003530. < PMID: 23935491 >

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