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CyFlow™ CD17 Purified

CyFlow™ CD17 Purified
Alternative Name: Lactosylceramide
Antibody: Yes
Antigen: CD17
Application: Flow cytometry
Clonality: monoclonal
Clone: MEM-68
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgM
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CX623074

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD17 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenNALM-6 human pre-B cell line
Background InformationCD17 (lactosylceramide) is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells.
Storage BufferThe reagent is provided in Tris buffered saline (TBS) solution, pH ≈8.0, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Bhunia AK, Arai T, Bulkley G, Chatterjee S: Lactosylceramide mediates tumor necrosis factor‑alpha‑induced intercellular adhesion molecule‑1 (ICAM‑1 expression and the adhesion of neutrophil in human umbilical vein endothelial cells. J Biol Chem. 1998 Dec 18; 273(51):34349‑57. < PMID: 9852101 > | Spychalska J, Smoleńska-Sym G, Zdebska E, Woźniak J, Kościelak J: Quantitative analysis of LacCer/CDw17 in human myelogenous leukaemic cells. Cell Mol Biol Lett. 2003; 8(4):911‑7. < PMID: 14668914 > | Pannu R, Singh AK, Singh I: A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha‑mediated proliferation of rat primary astrocytes: Implications for astrogliosis following neurotrauma. J Biol Chem. 2005 Apr 8; 280(14):13742‑51. < PMID: 15668227 > | Sharma DK, Brown JC, Cheng Z, Holicky EL, Marks DL, Pagano RE: The glycosphingolipid, lactosylceramide, regulates beta1‑integrin clustering and endocytosis. Cancer Res. 2005 Sep 15; 65(18):8233‑41. < PMID: 16166299 > | Zhai X, Li XM, Momsen MM, Brockman HL, Brown RE: Lactosylceramide: lateral interactions with cholesterol. Biophys J. 2006 Oct 1; 91(7):2490‑500. < PMID: 16829567 >

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