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CyFlow™ CD41 Low Endotoxin

CyFlow™ CD41 Low Endotoxin
Alternative Name: gpIIb
Antibody: Yes
Antigen: CD41
Application: Enzyme-linked immunosorbent assay, Flow cytometry, Functional assays, Immunohistochemistry, Immunoprecipitation
Clonality: monoclonal
Clone: MWReg30
Field of Interest: Immunophenotyping, MHC
Format/Fluorochrome: Low Endotoxin
Isotype: IgG1
Regulatory Status: RUO
Source Species: Rat
Target Species: Mouse
Product number: CA478931

For Research Use Only

Description Documentation TDS & SDS
Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD41 Low Endotoxin
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenMouse platelets
Background InformationCD41 (GPIIb; platelet glycoprotein IIb) is composed of two subunits (120 kDa GPIIb α and 23 kDa GPIIb β) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Storage BufferThe reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Sullivan BP, Wang R, Tawfik O, Luyendyk JP: Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci. 2010 May; 115(1):286‑94. < PMID: 20133375 > | Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C: Integrin αIIb (CD4{01} plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2013 Apr 11; 2(5):525‑32. < PMID: 23789102 > | Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M: A vasculo‑protective circuit centered on lipoxin A4 and aspirin‑triggered 15‑epi‑lipoxin A4 operative in murine microcirculation. Blood. 2013 Jul 25; 122(4):608‑17. < PMID: 23733341 > | Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX: Stress‑induced hematopoietic failure in the absence of immediate early response gene X‑1. Haematologica. 2013 Sep 20; < PMID: 23812939 >

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