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CyFlow™ CD134 PE

CyFlow™ CD134 PE
Alternative Name: OX40 , TNFRSF4
Antibody: Yes
Antigen: CD134
Application: Flow cytometry
Clonality: monoclonal
Clone: Ber-ACT35
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE
Isotype: IgG1
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human, Non-Human Primates
Product number: BV467980

For Research Use Only

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Description
HLDA Workshop HLDA VI—WS Code C-31 Quantity 100 tests Volume 1.0 mL Immunogen... more
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CyFlow™ CD134 PE

HLDA WorkshopHLDA VI—WS Code C-31
Quantity100 tests
Volume1.0 mL
ImmunogenHTLV 1-transformed HUT-102 cells
Background InformationCD134 (TNFRSF4, OX40) is a type I transmembrane glycoprotein of TNF/NGF receptor family expressed on activated T cells, fibroblasts, and hematopoietic precursors. Binding to its ligand (OX40L, TNFSF4) on antigen presenting cells gives to the T cell costimulatory signal, and this interaction results also in B cell proliferation and influences T cell memory pool. CD134 is upregulated at sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Jones D, Fletcher CD, Pulford K, Shahsafaei A, Dorfman DM: The T‑cell activation markers CD30 and OX40/CD134 are expressed in nonoverlapping subsets of peripheral T‑cell lymphoma. Blood. 1999 May 15; 93(10):3487‑93. < PMID: 10233901 > | Aten J, Roos A, Claessen N, Schilder-Tol EJ, Ten Berge IJ, Weening JJ: Strong and selective glomerular localization of CD134 ligand and TNF receptor‑1 in proliferative lupus nephritis. J Am Soc Nephrol. 2000 Aug; 11(8):1426‑38. < PMID: 10906156 > | Li M, Zhang Y: The effect of anti‑human CD134 monoclonal antibody on phytohemagglutinin‑induced mRNA expression of perforin in peripheral blood mononuclear cells. Cell Mol Immunol. 2005 Dec; 2(6):467‑71. < PMID: 16426498 > | Endl J, Rosinger S, Schwarz B, Friedrich SO, Rothe G, Karges W, Schlosser M, Eiermann T, Schendel DJ, Boehm BO: Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T‑cells in type 1 diabetes. Diabetes. 2006 Jan; 55(1):50‑60. < PMID: 16380476 > | Willett BJ, McMonagle EL, Ridha S, Hosie MJ: Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus. J Virol. 2006 Apr; 80(7):3386‑94. < PMID: 16537606 > | Tanijiri T, Shimizu T, Uehira K, Yokoi T, Amuro H, Sugimoto H, Torii Y, Tajima K, Ito T, Amakawa R, Fukuhara S: Hodgkin's reed‑sternberg cell line (KM‑H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells. J Leukoc Biol. 2007 Sep; 82(3):576‑84. < PMID: 17545218 > | Voo KS, Bover L, Harline ML, Vien LT, Facchinetti V, Arima K, Kwak LW, Liu YJ: Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function. J Immunol. 2013 Oct 1; 191(7):3641‑50. < PMID: 24014877 >

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