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CyFlow™ CD140b APC

CyFlow™ CD140b APC
Alternative Name: PDGFRB , PDGRF1
Antibody: Yes
Antigen: CD140b
Application: Flow cytometry
Clonality: monoclonal
Clone: 18A2
Emission Maximum: 660 nm
Excitation Maximum: 650 nm
Field of Interest: Immunophenotyping, Signaling
Format/Fluorochrome: APC
Isotype: IgG1
Laser: Red
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CN299595

For Research Use Only

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Description
Quantity 100 tests Volume 1.0 mL Immunogen CD140b-transfected NIH 3T3 cells... more
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CyFlow™ CD140b APC
Quantity100 tests
Volume1.0 mL
ImmunogenCD140b-transfected NIH 3T3 cells
Background InformationCD140b (PDGF-RB; platelet-derived growth factor receptor β) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a (PDGF-RA). Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumors such as medulloblastoma.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Andrae J, Gallini R, Betsholtz C: Role of platelet‑derived growth factors in physiology and medicine. Genes Dev. 2008 May 15; 22(10):1276‑312. < PMID: 18483217 > | French WJ, Creemers EE, Tallquist MD: Platelet‑derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep; 28(18):5646‑57. < PMID: 18606782 > | Schmahl J, Rizzolo K, Soriano P: The PDGF signaling pathway controls multiple steroid‑producing lineages. Genes Dev. 2008 Dec 1; 22(23):3255‑67. < PMID: 19056881 > | Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A: Platelet‑derived growth factor‑receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009 Aug; 11(8):732‑42. < PMID: 19649203 > | Fekete N, Rojewski MT, Fürst D, Kreja L, Ignatius A, Dausend J, Schrezenmeier H: GMP‑compliant isolation and large‑scale expansion of bone marrow‑derived MSC. PLoS One. 2012; 7(8):e43255. < PMID: 22905242 >

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