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CyFlow™ CD140b Purified

CyFlow™ CD140b Purified
Alternative Name: PDGFRB , PDGRF1
Antibody: Yes
Antigen: CD140b
Application: Flow cytometry, Immunocytochemistry
Clonality: monoclonal
Clone: 18A2
Field of Interest: Immunophenotyping, Signaling
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: BX650702

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD140b Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenCD140b-transfected NIH 3T3 cells
Background InformationCD140b (PDGF-RB; platelet-derived growth factor receptor β) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a (PDGF-RA). Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumors such as medulloblastoma.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Andrae J, Gallini R, Betsholtz C: Role of platelet‑derived growth factors in physiology and medicine. Genes Dev. 2008 May 15; 22(10):1276‑312. < PMID: 18483217 > | French WJ, Creemers EE, Tallquist MD: Platelet‑derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep; 28(18):5646‑57. < PMID: 18606782 > | Schmahl J, Rizzolo K, Soriano P: The PDGF signaling pathway controls multiple steroid‑producing lineages. Genes Dev. 2008 Dec 1; 22(23):3255‑67. < PMID: 19056881 > | Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A: Platelet‑derived growth factor‑receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009 Aug; 11(8):732‑42. < PMID: 19649203 > | Fekete N, Rojewski MT, Fürst D, Kreja L, Ignatius A, Dausend J, Schrezenmeier H: GMP‑compliant isolation and large‑scale expansion of bone marrow‑derived MSC. PLoS One. 2012; 7(8):e43255. < PMID: 22905242 >

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