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CyFlow™ CD161 PE

CyFlow™ CD161 PE
Alternative Name: NKR, NKR-P1A , NKRP1A
Antibody: Yes
Antigen: CD161
Application: Flow cytometry
Clonality: monoclonal
Clone: HP-3G10
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE
Isotype: IgG1
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human, Non-Human Primates
Product number: AY505662

For Research Use Only

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Description
Quantity 100 tests Volume 1.0 mL Immunogen Human NK cells Background Information... more
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CyFlow™ CD161 PE
Quantity100 tests
Volume1.0 mL
ImmunogenHuman NK cells
Background InformationCD161 (Nkrp1; natural killer receptor protein 1 or Klrb1; killer cell lectin-like receptor subfamily b member 1) is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Pozo D, Valés-Gómez M, Mavaddat N, Williamson SC, Chisholm SE, Reyburn H: CD161 (human NKR‑P1A) signaling in NK cells involves the activation of acid sphingomyelinase. J Immunol. 2006 Feb 15; 176(4):2397‑406. < PMID: 16455998 > | Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL: Gender specificity of altered human immune cytokine profiles in aging. FASEB J. 2010 Sep; 24(9):3580‑9. < PMID: 20453111 > | Tresoldi E, Dell'Albani I, Stabilini A, Jofra T, Valle A, Gagliani N, Bondanza A, Roncarolo MG, Battaglia M: Stability of human rapamycin‑expanded CD4+CD25+ T regulatory cells. Haematologica. 2011 Sep; 96(9):1357‑65. < PMID: 21565906 > | Germain C, Meier A, Jensen T, Knapnougel P, Poupon G, Lazzari A, Neisig A, Hakansson K, Dong T, Wagtmann N, Galsgaard ED, Spee P, Braud VM: Induction of lectin‑like transcript 1 (LLT{01} protein cell surface expression by pathogens and interferon‑γ contributes to modulate immune responses. J Biol Chem. 2011 Nov 4; 286(44):37964‑75. < PMID: 21930700 > | Fogal B, Yi T, Wang C, Rao DA, Lebastchi A, Kulkarni S, Tellides G, Pober JS: Neutralizing IL‑6 reduces human arterial allograft rejection by allowing emergence of CD161(+) CD4(+) T regulatory cells. J Immunol. 2011 Dec 15; 187(12):6268‑6280. < PMID: 22084439 > | Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VO: Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co‑Infection. PLoS One. 2013 Dec 31; 8(12):e83474. < PMID: 24391773 >

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