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CyFlow™ ABRA1 Purified

CyFlow™ ABRA1 Purified
Antibody: Yes
Antigen: ABRA1
Application: Flow cytometry, Immunoprecipitation, Western blot
Clonality: monoclonal
Clone: ABRA1-01
Field of Interest: Adaptor proteins, Transcription
Format/Fluorochrome: Purified
Isotype: IgG
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AP667270

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ ABRA1 Purified

Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenRecombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
Background InformationABRA1 (Abraxas, CCDC98) is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ: Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007 May 25; 316(5828):1194‑8. < PMID: 17525340 > | Liu Z, Wu J, Yu X: CCDC98 targets BRCA1 to DNA damage sites. Nat Struct Mol Biol. 2007 Aug; 14(8):716‑20. < PMID: 17643121 > | Wang B, Elledge SJ: Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci USA. 2007 Dec 26; 104(52):20759‑63. < PMID: 18077395 > | Nikkilä J, Coleman KA, Morrissey D, Pylkäs K, Erkko H, Messick TE, Karppinen SM, Amelina A, Winqvist R, Greenberg RA: Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function. Oncogene. 2009 Apr 23; 28(16):1843‑52. < PMID: 19305427 >

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