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CyFlow™ DDIT4L Purified

CyFlow™ DDIT4L Purified
Alternative Name: DNA-damage-inducible transcript 4 like , REDD-2, RTP801L
Antibody: Yes
Antigen: DDIT4L
Application: Flow cytometry, Western blot
Clonality: monoclonal
Clone: DDIT-03
Field of Interest: Apoptosis
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AN275508

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ DDIT4L Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenN-terminal recombinant fragment of human DDIT4L (amino acids 2-98)
Background InformationDDIT4L (DNA-damage-inducible transcript 4-like), also known as REDD2 (regulated in development and DNA damage response 2) or RTP801L is a stress-inducted protein, which was shown to mediate monocyte cell death through a reduction in thioredoxin-1 expression, and is highly expressed in atherosclerotic lesions. Stimulation of DDIT4L expression in macrophages increases oxidized LDL-induced macrophage death.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Cuaz-Pérolin C, Furman C, Larigauderie G, Legedz L, Lasselin C, Copin C, Jaye M, Searfoss G, Yu KT, Duverger N, Negre-Salvayre A, Fruchart JC, Rouis M: REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1830‑5. < PMID: 15308555 > | Corradetti MN, Inoki K, Guan KL: The stress‑inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18; 280(11):9769‑72. < PMID: 15632201 > | Imen JS, Billiet L, Cuaz-Pérolin C, Michaud N, Rouis M: The regulated in development and DNA damage response 2 (REDD2) gene mediates human monocyte cell death through a reduction in thioredoxin‑1 expression. Free Radic Biol Med. 2009 May 15; 46(10):1404‑10. < PMID: 19268525 >

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