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CyFlow™ EGFR Purified

CyFlow™ EGFR Purified
Antibody: Yes
Antigen: EGFR
Application: Flow cytometry, Immunocytochemistry, Immunohistochemistry (frozen sections), Immunoprecipitation
Clonality: monoclonal
Clone: EGFR1
Field of Interest: Phosphorylation
Format/Fluorochrome: Purified
Isotype: IgG2b
Regulatory Status: RUO
Source Species: Mouse
Target Species: Horse, Human
Product number: AX065549

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ EGFR Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenHuman epidermoid carcinoma line A431
Background InformationOncoprotein EGFR (epidermal growth factor receptor), also known as HER1 or ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2/ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Akiyama M, Smith LT, Shimizu H: Changing patterns of localization of putative stem cells in developing human hair follicles. J Invest Dermatol. 2000 Feb; 114(2):321‑7. < PMID: 10651993 > | Aigner A, Juhl H, Malerczyk C, Tkybusch A, Benz CC, Czubayko F: Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation. Oncogene. 2001 Apr 19; 20(17):2101‑11. < PMID: 11360194 > | Fortunel NO, Hatzfeld JA, Rosemary PA, Ferraris C, Monier MN, Haydont V, Longuet J, Brethon B, Lim B, Castiel I, Schmidt R, Hatzfeld A: Long‑term expansion of human functional epidermal precursor cells: promotion of extensive amplification by low TGF‑beta1 concentrations. J Cell Sci. 2003 Oct 1; 116(19):4043‑52. < PMID: 12953061 > | Rebetz J, Tian D, Persson A, Widegren B, Salford LG, Englund E, Gisselsson D, Fan X: Glial progenitor‑like phenotype in low‑grade glioma and enhanced CD133‑expression and neuronal lineage differentiation potential in high‑grade glioma. PLoS One. 2008 Apr 9; 3(4):e1936. < PMID: 18398462 >

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