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CyFlow™ IgE Purified

CyFlow™ IgE Purified
Antibody: Yes
Antigen: IgE
Application: Enzyme-linked immunosorbent assay, Flow cytometry
Clonality: monoclonal
Clone: 4H10
Field of Interest: Immunoglobulins
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: BN409324

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ IgE Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenPurified human IgE
Background InformationImmunoglobulin E (IgE) is a 180 kDa soluble protein serving as an antigen-specific unit of mast cell effector mechanisms. IgE has the lowest serum concentration of all immunoglobulins (approximately 0.5 mg/l) in healthy individuals, but upon allergen challenge its concentration in blood increases dramatically. Although biological survival of free IgE is very short (T1/2 = 2 days), it is stabilized after binding to its high affinity receptor. Unlike IgM- IgG- and IgA-committed B cells, IgE-switched B cells do not undergo clonal expansion.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975; 194:77‑95. < PMID: 47690 > | Fuller JM, Keyser JW: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May; 21(6):667‑71. < PMID: 1122610 > | Balogh Z, Merétey K, Falus A, Bozsóky S: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr; 39(2):129‑34. < PMID: 6966908 > | Brinkmann V, Heusser CH: T cell‑dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec; 152(2):323‑32. < PMID: 8258141 > | Gould HJ, Beavil RL, Vercelli D: IgE isotype determination: epsilon‑germline gene transcription, DNA recombination and B‑cell differentiation. Br Med Bull. 2000; 56(4):908‑24. < PMID: 11359628 >

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