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CyFlow™ LARGE1 PE

CyFlow™ LARGE1 PE
Antibody: Yes
Antigen: LARGE1
Application: Flow cytometry
Clonality: monoclonal
Clone: LARGE-02
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Others
Format/Fluorochrome: PE
Isotype: IgG2b
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CF600136

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 0,1 Quantity 0.1 mg Volume 1.0 mL... more
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CyFlow™ LARGE1 PE
Concentration Unitmg/mL
Concentration0,1
Quantity0.1 mg
Volume1.0 mL
ImmunogenRecombinant fragment of human LARGE1 (amino acids 35-142)
Background InformationLARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein α-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of α-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered α-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
UsageThe reagent is designed for Flow Cytometry analysis. Working concentrations should be determined by the investigator.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE: Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies. Glycobiology. 2005 Oct; 15(10):912‑23. < PMID: 15958417 >

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