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CyFlow™ CD3 act. Purified

CyFlow™ CD3 act. Purified
Antibody: Yes
Antigen: CD3 (activation epitope)
Application: Flow cytometry, Immunocytochemistry, Immunohistochemistry (frozen sections), Immunoprecipitation, Western blot
Clonality: monoclonal
Clone: APA1/1
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human, Mouse
Product number: CF594139

For Research Use Only

HLDA Workshop HLDA III—WS Code T 126 Concentration Unit mg/mL Concentration 1... more
CyFlow™ CD3 act. Purified
HLDA WorkshopHLDA III—WS Code T 126
Concentration Unitmg/mL
Quantity0.1 mg
Volume0.1 mL
ImmunogenPurified human CD3 proteins isolated from thymus
Background InformationCD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3γ, CD3 δ, CD3ε and CD3ζ. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

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