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CyFlow™ CD11a Low Endotoxin

CyFlow™ CD11a Low Endotoxin
Alternative Name: LFA-1
Antibody: Yes
Antigen: CD11a
Application: Flow cytometry, Functional assays, Immunohistochemistry (frozen sections), Immunoprecipitation
Clonality: monoclonal
Clone: M17/4
Field of Interest: Immunophenotyping, MHC
Format/Fluorochrome: Low Endotoxin
Isotype: IgG2a
Regulatory Status: RUO
Source Species: Rat
Target Species: Mouse
Product number: CH435905

For Research Use Only

Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
CyFlow™ CD11a Low Endotoxin
Concentration Unitmg/mL
Quantity0.1 mg
Volume0.1 mL
ImmunogenC57BL/6 mouse splenic secondary cytotoxic T lymphocytes
Background InformationCD11a (LFA-1 α) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the αLβ2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.
Storage BufferThe reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

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