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CyFlow™ CD61 APC-Cy7

CyFlow™ CD61 APC-Cy7
Alternative Name: GPIIIa
Antibody: Yes
Antigen: CD61
Application: Flow cytometry
Clonality: monoclonal
Clone: VIPL2
Emission Maximum: 780 nm
Excitation Maximum: 650 nm, 750 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: APC-Cy7
Isotype: IgG1
Laser: Red
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human, Non-Human Primates
Product number: CP539133

For Research Use Only

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Description
HLDA Workshop HLDA V—WS Code 5T-124 Quantity 100 tests Volume 0.4 mL Immunogen... more
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CyFlow™ CD61 APC-Cy7
HLDA WorkshopHLDA V—WS Code 5T-124
Quantity100 tests
Volume0.4 mL
ImmunogenNot available
Background InformationCD61 (β3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buck DW, Schmitz J: BDCA‑2, BDCA‑3, and BDCA‑4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol. 2000 Dec 1; 165(11):6037‑46. < PMID: 11086035 > | Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MK: VLA‑2 (alpha2beta{01} integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109‑23. < PMID: 11773387 > | Roberts MS, Woods AJ, Dale TC, Van Der Sluijs P, Norman JC: Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol Cell Biol. 2004 Feb; 24(4):1505‑15. < PMID: 14749368 > | Mondal D, Williams CA, Ali M, Eilers M, Agrawal KC: The HIV‑1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp Biol Med (Maywood). 2005 Oct; 230(9):631‑44. < PMID: 16179731 > | Williams CA, Mondal D, Agrawal KC: The HIV‑1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP. Exp Biol Med (Maywood). 2005 Dec; 230(11):872‑84. < PMID: 16339753 > | Barrett L, Dai C, Gamberg J, Gallant M, Grant M: Circulating CD14‑CD36+ peripheral blood mononuclear cells constitutively produce interleukin‑10. J Leukoc Biol. 2007 Jul; 82(1):152‑60. < PMID: 17412916 >

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