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CyFlow™ CD70 PE

CyFlow™ CD70 PE
Alternative Name: CD27L, Ki-24 , TNFSF7
Antibody: Yes
Antigen: CD70
Application: Flow cytometry
Clonality: monoclonal
Clone: Ki-24
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE
Isotype: IgG3
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: BJ865406

For Research Use Only

Description Documentation TDS & SDS
Description
Quantity 100 tests Volume 1.0 mL Immunogen Not available Background Information... more
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CyFlow™ CD70 PE
Quantity100 tests
Volume1.0 mL
ImmunogenNot available
Background InformationCD70 (TNFSF7, CD27L) is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Israel BF, Pickles RJ, Segal DM, Gerard RD, Kenney SC: Enhancement of adenovirus vector entry into CD70‑positive B‑cell Lines by using a bispecific CD70‑adenovirus fiber antibody. J Virol. 2001 Jun; 75(11):5215‑21. < PMID: 11333903 > | Kaufmann Y, Amariglio N, Rosenthal E, Hirsch YJ, Many A, Rechavi G: Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low‑grade lymphoma. J Immunol. 2005 Nov 15; 175(10):6940‑7. < PMID: 16272354 > | Kaufmann Y, Amariglio N, Rosenthal E, Hirsch YJ, Many A, Rechavi G: Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low‑grade lymphoma. J Immunol. 2005 Nov 15; 175(10):6940‑7. < PMID: 16272354 > | Hashimoto-Okada M, Kitawaki T, Kadowaki N, Iwata S, Morimoto C, Hori T, Uchiyama T: The CD70‑CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans. Int Immunol. 2009 Aug; 21(8):891‑904. < PMID: 19556308 > | Trebing J, El-Mesery M, Schäfer V, Weisenberger D, Siegmund D, Silence K, Wajant H: CD70‑restricted specific activation of TRAILR1 or TRAILR2 using scFv‑targeted TRAIL mutants. Cell Death Dis. 2014 Jan 30; 5:e1035. < PMID: 24481449 >

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