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CyFlow™ CD79a Purified

CyFlow™ CD79a Purified
Alternative Name: IgA , MB-1, MB1
Antibody: Yes
Antigen: CD79a
Application: Flow cytometry, Immunohistochemistry
Clonality: monoclonal
Clone: HM57
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Chicken, Cow, Guinea pig, Horse, Human, Mouse, Opossum, Pig, Rabbit, Rat
Product number: AA059748

For Research Use Only

HLDA Workshop HLDA V—WS Code BC cB018 HLDA VI—WS Code BP 193 HLDA VI—WS Code BP 89 HLDA VI—WS... more
CyFlow™ CD79a Purified
HLDA WorkshopHLDA V—WS Code BC cB018 HLDA VI—WS Code BP 193 HLDA VI—WS Code BP 89 HLDA VI—WS Code B B103 HLDA VI—WS Code B CD79.4
Concentration Unitmg/mL
Quantity0.1 mg
Volume0.1 mL
ImmunogenSynthetic peptide corresponding to amino acids 202-216 of human CD79a
Background InformationCD79a (Ig α, MB1) forms disulfide-linked heterodimer with CD79b (Ig β, B29). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with λ5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

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