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CyFlow™ CD85j Low Endotoxin

CyFlow™ CD85j Low Endotoxin
Alternative Name: LIR-1 , LIR1 ILT2
Antibody: Yes
Antigen: CD85j
Application: Flow cytometry, Functional assays, Immunoprecipitation, Western blot
Clonality: monoclonal
Clone: GHI/75
Field of Interest: Immunophenotyping
Format/Fluorochrome: Low Endotoxin
Isotype: IgG2b
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AG729790

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD85j Low Endotoxin
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenHairy cell leukemia cells
Background InformationCD85j (ILT-2; Ig-like transcript 2, LIR-1; leukocyte Ig-like receptor 1 or LILRB1; leukocyte Ig-like receptor B1) is a member of Ig superfamily transmembrane glycoproteins named CD85. The CD85j protein is expressed on several types of immune cells (plasma cells, B cells, monocytes, T and NK cell subsets) where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
Storage BufferThe reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Doussis IA, Gatter KC, Mason DY: CD68 reactivity of non‑macrophage derived tumours in cytological specimens. J Clin Pathol. 1993 Apr; 46(4):334‑6. < PMID: 7684403 > | Banham AH, Colonna M, Cella M, Micklem KJ, Pulford K, Willis AC, Mason DY: Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily. J Leukoc Biol. 1999 Jun; 65(6):841‑5. < PMID: 10380908 > | Riteau B, Menier C, Khalil-Daher I, Martinozzi S, Pla M, Dausset J, Carosella ED, Rouas-Freiss N: HLA‑G1 co‑expression boosts the HLA class I‑mediated NK lysis inhibition. Int Immunol. 2001 Feb; 13(2):193‑201. < PMID: 11157852 > | Lo Monaco E, Tremante E, Cerboni C, Melucci E, Sibilio L, Zingoni A, Nicotra MR, Natali PG, Giacomini P: Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells. Neoplasia. 2011 Sep; 13(9):822‑30. < PMID: 21969815 >

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