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CyFlow™ CD116 PE

CyFlow™ CD116 PE
Alternative Name: GM-CSFR a-subunit , GMCSFR, GMR
Antibody: Yes
Antigen: CD116
Application: Flow cytometry
Clonality: monoclonal
Clone: 4H1
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE
Isotype: IgG1
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: BT220180

For Research Use Only

Quantity 100 tests Volume 1.0 mL Immunogen CD116-transfected COS cells Background... more
CyFlow™ CD116 PE
Quantity100 tests
Volume1.0 mL
ImmunogenCD116-transfected COS cells
Background InformationCD116 (GM-CSF R α) is the low affinity receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF). CD116 heterodimerizes with CD131, the common β chain subunit shared with IL-3 and IL-5 receptors, to form the high affinity GM-CSF receptor. CD116 is expressed by myeloid cells including macrophages, neutrophils, eosinophils, dendritic cells, and their precursors, as well as on endothelial cells. It is being used as a specific marker of myeloid leukemias.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF: Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte‑macrophage colony‑stimulating factor, and interleukin 5 receptors essential for disulfide‑linked receptor heterodimerization and activation of all three receptors. J Biol Chem. 1998 Jan 9; 273(2):1192‑9. < PMID: 9422786 > | Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, Corcuff E, Mortier E, Jacques Y, Spits H, Di Santo JP: IL‑15 trans‑presentation promotes human NK cell development and differentiation in vivo. J Exp Med. 2009 Jan 16; 206(1):25‑34. < PMID: 19103877 > | Schwarzmaier D, Foell D, Weinhage T, Varga G, Däbritz J: Peripheral monocyte functions and activation in patients with quiescent Crohn's disease. PLoS One. 2013 Apr 26; 8(4):e62761. < PMID: 23658649 > | Koba C, Haruta M, Matsunaga Y, Matsumura K, Haga E, Sasaki Y, Ikeda T, Takamatsu K, Nishimura Y, Senju S: Therapeutic effect of human iPS‑cell‑derived myeloid cells expressing IFN‑β: against peritoneally disseminated cancer in xenograft models. PLoS One. 2013 Jun 24; 8(6):e67567. < PMID: 23826321 >