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CyFlow™ CD120a Purified

CyFlow™ CD120a Purified
Alternative Name: p55, TNFR1 , TNFRp55, TNFRSF1A
Antibody: Yes
Antigen: CD120a
Application: Flow cytometry, Functional assays, Immunohistochemistry, Immunoprecipitation
Clonality: monoclonal
Clone: H398
Field of Interest: Immunophenotyping, Signaling
Format/Fluorochrome: Purified
Isotype: IgG2a
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: BA946183

For Research Use Only

Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
CyFlow™ CD120a Purified
Concentration Unitmg/mL
Quantity0.1 mg
Volume0.1 mL
ImmunogenRecombinant full length human CD120a
Background InformationCD120a (TNF R1,TNFR55 or TNFRSF1A) is a 55 kDa receptor for tumor necrosis factor α and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Kohrgruber N1, Halanek N, Gröger M, Winter D, Rappersberger K, Schmitt-Egenolf M, Stingl G, Maurer D: Survival, maturation, and function of CD11c‑ and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines. J Immunol. 1999 Sep 15; 163(6):3250‑9. < PMID: 10477594 > | Baker PK, Pettitt AR, Slupsky JR, Chen HJ, Glenn MA, Zuzel M, Cawley JC: Response of hairy cells to IFN‑alpha involves induction of apoptosis through autocrine TNF‑alpha and protection by adhesion. Blood. 2002 Jul 15; 100(2):647‑53. < PMID: 12091360 > | Buckley CD1, Ross EA, McGettrick HM, Osborne CE, Haworth O, Schmutz C, Stone PC, Salmon M, Matharu NM, Vohra RK, Nash GB, Rainger GE: Identification of a phenotypically and functionally distinct population of long‑lived neutrophils in a model of reverse endothelial migration. J LeukocBiol. 2006 Feb; 79(2):303‑11. < PMID: 16330528 >