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CyFlow™ CD144 Purified

CyFlow™ CD144 Purified
Alternative Name: 7B4, cadherin-5, CDH5, VE-cadherin
Antibody: Yes
Antigen: CD144
Application: Flow cytometry, Immunocytochemistry, Immunohistochemistry (frozen sections), Immunoprecipitation, Western blot
Clonality: monoclonal
Clone: 55-7H1
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CP087269

For Research Use Only

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD144 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenHuman endothelial cells
Background InformationCD144 (VE-cadherin, cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (δ1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| De Ugarte DA, Alfonso Z, Zuk PA, Elbarbary A, Zhu M, Ashjian P, Benhaim P, Hedrick MH, Fraser JK: Differential expression of stem cell mobilization‑associated molecules on multi‑lineage cells from adipose tissue and bone marrow. Immunol Lett. 2003 Oct 31; 89(2‑3):267‑70. < PMID: 14556988 > | Limaye V, Li X, Hahn C, Xia P, Berndt MC, Vadas MA, Gamble JR: Sphingosine kinase‑1 enhances endothelial cell survival through a PECAM‑1‑dependent activation of PI‑3K/Akt and regulation of Bcl‑2 family members. Blood. 2005 Apr 15; 105(8):3169‑77. < PMID: 15632208 > | Hamilton RD, Foss AJ, Leach L: Establishment of a human in vitro model of the outer blood‑retinal barrier. J Anat. 2007 Dec; 211(6):707‑16. < PMID: 17922819 > | Agrawal V, Kelly J, Tottey S, Daly KA, Johnson SA, Siu BF, Reing J, Badylak SF: An isolated cryptic peptide influences osteogenesis and bone remodeling in an adult mammalian model of digit amputation. Tissue Eng Part A. 2011 Dec; 17(23‑24):3033‑44. < PMID: 21740273 > | Tisato V, Zauli G, Voltan R, Gianesini S, di Iasio MG, Volpi I, Fiorentini G, Zamboni P, Secchiero P: Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro‑inflammatory phenotype. PLoS One. 2012; 7(6): < PMID: 22737245 > | Dejana E, Orsenigo F: Endothelial adherens junctions at a glance. J Cell Sci. 2013 Jun 15; 126(Pt 12):2545‑9. < PMID: 23781019 >

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