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CyFlow™ CD146 Purified

CyFlow™ CD146 Purified
Alternative Name: MCAM , Mel-CAM, MUC18, s-endo
Antibody: Yes
Antigen: CD146
Application: Flow cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western blot
Clonality: monoclonal
Clone: P1H12
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Dog, Human, Mouse, Rabbit
Product number: AV721526

For Research Use Only

Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
CyFlow™ CD146 Purified
Concentration Unitmg/mL
Quantity0.1 mg
Volume0.1 mL
ImmunogenCultured human umbilical cells
Background InformationCD146 (MCAM; melanoma cell adhesion molecule or MUC18) is a heavily glycosylated transmembrane glycoprotein with more than 50% of the mass from carbohydrates. It is expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, activated T cells and activated keratinocytes, and on some cancer cells, especially melanoma. The presence of CD146 on circulating blood cells has been confined to the activated T cells rather than circulating endothelial cells. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP: Circulating activated endothelial cells in sickle cell anemia. N Engl J Med. 1997 Nov 27; 337(22):1584‑90. < PMID: 9371854 > | Solovey AN, Gui L, Chang L, Enenstein J, Browne PV, Hebbel RP: Identification and functional assessment of endothelial P1H12. J Lab Clin Med. 2001 Nov; 138(5):322‑31. < PMID: 11709656 > | Kamstock D, Guth A, Elmslie R, Kurzman I, Liggitt D, Coro L, Fairman J, Dow S: Liposome‑DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma. Cancer Gene Ther. 2006 Mar; 13(3):306‑17. < PMID: 16138118 > | Finney MR, Greco NJ, Haynesworth SE, Martin JM, Hedrick DP, Swan JZ, Winter DG, Kadereit S, Joseph ME, Fu P, Pompili VJ, Laughlin MJ: Direct comparison of umbilical cord blood versus bone marrow‑derived endothelial precursor cells in mediating neovascularization in response to vascularischemia. Biol Blood Marrow Transplant. 2006 May; 12(5):585‑93. < PMID: 16635794 >